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PUBLICATIONS

References and Links to Papers

VOLUME 1 - MARCH 2023

Published March 10th, 2023

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ABSTRACT

This clinical case describes the successful treatment of psoriasis vulgaris in a patient through a multifaceted approach including dietary modifications, vitamin D supplementation, and probiotics. Initial laboratory findings revealed an ANA (+) result, lipid abnormalities, and a deficiency in cholecalciferol and calcitriol. The patient was prescribed 60,000 IU of cholecalciferol with necessary cofactors, leading to partial improvement in symptoms after five months. The dose was increased to 100,000 IU D3, and probiotics were added to the regimen. After nine months of treatment, complete remission of psoriasis was observed, with laboratory findings showing significant improvements in calcifediol and calcitriol levels, normal Ca+ levels, and lower PTH. These results demonstrate the potential benefits of a comprehensive approach to managing psoriasis, addressing underlying nutritional deficiencies, dysbiosis and lifestyle factors.

Published March 22nd, 2023

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ABSTRACT

Vitamin D is an essential nutrient that plays a crucial role in maintaining  bone  health,  immune  function,  and  overall health. Adequate levels of vitamin D are important for proper calcium absorption, regulation of gene expression, and modulation of immune responses. However, patients with   autoimmune   diseases   may   have   genetic polymorphisms that contribute to vitamin D resistance, such as single nucleotide polymorphisms (SNPs) affecting the genes CYP2R1, CYP27B1, VDR, and VDBP.

In addition, these patients may have ongoing leaky gut syndrome due to inflammatory foods, such as gluten, dairy, lectins, and sugars, which can lead to molecular mimicry and the production of autoantibodies. This condition sets the  stage  for  foreign  proteins  and  toxins,  including lipopolysaccharides,   endotoxins,   exotoxins,   and mycotoxins, to enter the bloodstream, further inducing the production of autoantibodies.

Bacterial, fungal, and viral infections can also contribute to vitamin D resistance by downregulating the expression of vitamin  D  receptors,  and  this  mechanism  is  often overlooked. For instance, studies have shown that some viruses, such as HIV, HSV1, HCV, and EBV, can suppress VDR expression and vitamin D signaling pathways, leading to  decreased  immune  response  and  increased  viral replication

Understanding the mechanisms by which these toxins and infections impact vitamin D receptor expression, end up creating a contributing factor for vitamin D resistance that is sometimes  overlooked  on  behalf  healthcare  providers. Additionally, we have learned a great deal from high dose vitamin  D  therapy  supplementation  alongside  anti- inflammatory dietary which has been shown to reduce degree of dysbiosis and intestinal permeability giving time for our cells to in order to upregulate VDRs in our immune cells and restore our immunologic tolerance once again.

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Published March 25th, 2023

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ABSTRACT

Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects joints, causing inflammation, stiffness, and pain. Current  treatments  focus  on  managing  symptoms  and preventing joint damage, but recent studies have shown that vitamin D deficiency is common in RA patients, and low levels of vitamin D may contribute to the development and progression of RA. The LGS protocol cited in this article, includes high-dose vitamin D + cofactors, along side an anti- inflammatory diet, with the use probiotics, which has shown promising results in managing RA symptoms. This clinical case described in this article highlights the multifaceted approach required to manage RA, including medication, lifestyle changes, patient education, and regular follow-up and monitoring. The LGS (Leaky Gut Syndrome) Protocol, offers a promising new approach to managing RA patients. HDVD + AID is a very safe and viable therapeutic option that healthcare providers show look into.

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